The literature review of Ollier disease

Enchondroma is a common, benign, hyaline-cartilage-forming tumor in the medulla of the bone, occurs at metaphysis or extended to diaphysis, and usually a single lesion. When there are multiple enchondromas, the term enchondromatosis is applied. There are 7 subtypes of enchondromatosis; the most common subtypes are Ollier disease and Maffucci syndrome which are distinguished by the presentation of hemangioma. When enchondromatosis presents with hemangioma, it is named Maffucci syndrome, without hemangioma is named Ollier disease. Ollier disease is also known as dyschondroplasia, multiple cartilaginous enchondromatosis or enchondromatosis Spranger type I. It is a rare non-hereditary congenital disease. The incidence is 1:100,000 but can be higher because of the under-detection of the mild phenotypes without skeletal deformities [1]. There is no difference between male and female. Pathogenesis